Interstate 95 (I-95) is an Interstate Highway on the east coast of the United States, connecting Florida to Maine. Within the state of New Hampshire, it serves the Seacoast Region and is a toll road named the Blue Star Turnpike or New Hampshire Turnpike. The 16.11-mile (25.93 km) turnpike is maintained by the New Hampshire Department of Transportation (NHDOT) Bureau of Turnpikes and has a single toll plaza near Hampton.

The Seacoast Region is the southeast area of the U.S. state of New Hampshire that is centered around the city of Portsmouth. It includes the eastern portion of Rockingham County and the southern portion of Strafford County. At its narrowest definition, the region stretches 13 miles (21 km) along the Atlantic Ocean from New Hampshire's border with Salisbury, Massachusetts, to the Piscataqua River and New Hampshire's border with Kittery, Maine. The shoreline alternates between rocky and rough headlands and areas with sandy beaches. Some of the beaches are bordered by jetties or groins, particularly in the towns of Rye and Hampton. Most definitions of the Seacoast Region includes some inland towns as well, including the Great Bay area cities of Dover and Rochester, the college town of Durham, and areas as far west as Epping. Some definitions also include nearby portions of York County, Maine that are culturally aligned with the Portsmouth area rather than the Portland, Maine metropolitan area.