Interstate 99 (I-99) is an interstate highway in the United States with two segments: one located in central Pennsylvania and the other in southern New York. The southern terminus of the route is near exit 146 of the Pennsylvania Turnpike (I-70/I-76) north of Bedford, where the road continues south as U.S. Route 220 (US 220). The northern terminus of the Pennsylvania segment is at an at-grade intersection with Musser Lane just before reaching I-80 near Bellefonte. The New York segment follows US 15 from the Pennsylvania–New York border to an interchange with I-86 in Corning. Within Pennsylvania, I-99 passes through Altoona and State College—the latter home to the Pennsylvania State University—and is entirely concurrent with US 220. Long-term plans call for the two segments of I-99 to be connected using portions of I-80, US 220, and US 15 through Pennsylvania.

The Pennsylvania Turnpike is a controlled-access toll road that is operated by the Pennsylvania Turnpike Commission (PTC) in the Commonwealth of Pennsylvania in the United States. It runs for 360 miles (580 km) across the state, connecting Pittsburgh in Western Pennsylvania with Philadelphia in eastern Pennsylvania, and passes through four tunnels as it crosses the Appalachian Mountains in central Pennsylvania.