Iowa Highway 1 (Iowa 1) is a state highway in the U.S. state of Iowa that extends from Keosauqua to Anamosa. It travels nearly 120 miles (190 km), mainly through rich farmland and small communities. Iowa 1 provides an important link to Iowa City and the University of Iowa as it passes through campus. Portions of the route today date back to the late 1830s, when Martin Van Buren was president, making Iowa 1 one of the oldest routes in the state, pre-dating the current primary highway system by nearly eighty years. The highway was seriously damaged by the Cedar River in the Iowa flood of 2008, which closed the highway for seven weeks.

Iowa City is the county seat and largest city of Johnson County, Iowa, United States. At the time of the 2020 census the population was 74,828, making it the state's fifth-most populous city. The Iowa City metropolitan area, which encompasses Johnson and Washington counties, has a population of over 171,000. The metro area is also a part of a combined statistical area with the Cedar Rapids metro area known as the Iowa City-Cedar Rapids region which collectively has a population of nearly 500,000.