Iowa Highway 163 is a state highway that travels from U.S. Highway 69 in Des Moines to US 63 near Oskaloosa. The Iowa Department of Transportation has signed Iowa 163 from Oskaloosa to Burlington along US 63 and US 34, but it does not officially recognize those sections of road as part of the route.

U.S. Highway 63 (US 63) is a United States Highway that runs through the eastern third of Iowa. It begins at the Missouri state line southwest of Bloomfield and travels north through Ottumwa, Oskaloosa, Tama, Waterloo, and New Hampton. It ends at the Minnesota state line at Chester. Between Ottumwa and Oskaloosa, the highway is a four-lane controlled-access highway. Through Waterloo and New Hampton, it is partially controlled; that is, the road as both grade-separated interchanges and at-grade intersections. The rest of the highway is largely a two-lane rural highway.