Iowa Highway 22 (Iowa 22) is a 98-mile (158 km) west–east state highway that traverses primarily rural areas in east-central Iowa. The highway begins near Thornburg at an intersection with Iowa Highway 21 and ends in southwestern Davenport, at U.S. Highway 61 Business.

Davenport is a city in and the county seat of Scott County, Iowa, United States. Located along the Mississippi River on the eastern border of the state, it is the largest of the Quad Cities, a metropolitan area with a population of 384,324 and a combined statistical area population of 474,019, ranking as the 147th-largest MSA and 91st-largest CSA in the nation. According to the 2020 census, the city had a population of 101,724, making it Iowa's third-most populous city after Des Moines and Cedar Rapids. Davenport was founded on May 14, 1836, by Antoine Le Claire and named for his friend George Davenport.