Iowa Highway 25 (Iowa 25) is a north–south highway in the southwest and west-central portion of the state. It begins at Iowa 2 seven miles (11 km) south of Clearfield. It heads north along a two-lane road through Creston, Greenfield, and Guthrie Center on its way to its northern end at U.S. Route 30 (US 30) near Scranton.

Iowa Highway 2 is a 251-mile-long (404 km) state highway which runs across the southernmost tier of counties in the U.S. state of Iowa. At no point along its route is Iowa 2 more than 15 miles (24 km) from the Missouri state line, except for a small section near its eastern terminus. Iowa 2 stretches across the entire state; from the Missouri River near Nebraska City, Nebraska, to U.S. Highway 61 (US 61) at Fort Madison. Prior to becoming a primary highway, the route was known as the Waubonsie Trail.