Iowa Highway 4 is a state highway which runs from north to south across the state of Iowa. It is 146 miles (235 km) long, beginning at an intersection with Iowa Highway 44 in Panora and ending at the Minnesota state line north of Estherville. It continues north as Minnesota State Highway 4. The route was created on January 1, 1969, when several route designations were changed to match other states' route numbers. Before 1969, Iowa 4 was known as Iowa 17.

Iowa Highway 141 (Iowa 141) is an east–west highway in the western and central portions of the state. It is the most direct link between Sioux City and Des Moines. It also serves as an expressway link between Des Moines and the outlying communities of Perry, Granger, and Grimes. Iowa 141 begins near Sloan at an interchange with Interstate 29 (I-29) at ends at another interchange with I-35 /I-80 on the edge of the Des Moines suburbs of Urbandale and Grimes.