Isaac Franklin was an American slave trader and plantation owner. Born to wealthy planters in what would become Sumner County, Tennessee, he assisted his brothers in trading slaves and agricultural surplus along the Mississippi River in his youth, before briefly serving in the Tennessee militia during the War of 1812. He returned to slave trading soon after the war, buying enslaved people in Virginia and Maryland, before marching them in coffles to sale at Natchez, Mississippi. He introduced John Armfield to the slave trade, and with him founded the Franklin & Armfield partnership in 1828, which would go on to become one of the largest slave trading firms in the United States. With a base of operations in Alexandria, D.C., the company shipped massive numbers of the enslaved by land and sea to markets at Natchez and New Orleans.

Natchez, officially the City of Natchez, is the only city in and the county seat of Adams County, Mississippi, United States. The population was 14,520 at the 2020 census. Located on the Mississippi River across from Vidalia in Concordia Parish, Louisiana, Natchez was a prominent city in the antebellum years, a center of cotton planters and Mississippi River trade.