The Isaiah Davenport House is a historic home in Savannah, Georgia, United States, built in 1820. It has been operated as a historic house museum by the Historic Savannah Foundation since 1963.

Savannah is the oldest city in the U.S. state of Georgia and the county seat of Chatham County. Established in 1733 on the Savannah River, the city of Savannah became the British colonial capital of the Province of Georgia and later the first state capital of Georgia. A strategic port city in the American Revolution and during the American Civil War, Savannah is today an industrial center and an important Atlantic seaport. It is Georgia's fifth most populous city, with a 2020 U.S. census population of 147,780. The Savannah metropolitan area, Georgia's third-largest, had a 2020 population of 404,798.