Isaiah Washington IV is an American actor and film producer. Following a series of film appearances, he came to prominence for portraying Dr. Preston Burke in the first three seasons of the series Grey's Anatomy from 2005 to 2007.

Preston Xavier Burke, M.D., F.A.C.S. is a fictional character from the medical drama television series Grey's Anatomy, which airs on ABC in the United States. The character was created by series producer Shonda Rhimes, and was portrayed by actor Isaiah Washington from 2005 to 2007. Introduced as an attending cardiothoracic surgeon at the fictional Seattle Grace Hospital, Burke's romantic relationship with intern Cristina Yang formed one of the main storylines in the shows' first three seasons.