Iseo is a town and comune in the province of Brescia, in Lombardy, Italy, on the south shore of Lake Iseo. It is bounded by the communes of Provaglio d'Iseo, Sulzano, Polaveno and Paratico.

Lake Iseo or Iseo lake, also known as Sebino, is the fourth largest lake in Lombardy, Italy, fed by the Oglio River.