The Isidora Sekulić Award is a Serbian, and former Yugoslav, literary prize established by the Belgrade municipality of Savski venac in 1967 and awarded annually since 1968 in honor of the writer and Belgrade native Isidora Sekulić. The award honors writers for the best work of modern Serbian literature of the previous year. In its first decade, several authors were awarded annually. Since 1979, only one author has received the award each year. A total of 71 authors have received the award since its inception.

Isidora Sekulić was a Serbian writer, novelist, essayist, polyglot and art critic. She was "the first woman academic in the history of Serbia" after she joined the Serbian Academy of Sciences and Arts in 1950.