Francisco Moreno Domagoso, also known as Isko Moreno Domagoso or simply Isko Moreno, is a Filipino politician, actor, host and entrepreneur who served as the 27th Mayor of Manila, the capital city of the Philippines, from 2019 to 2022. Before entering politics, Moreno first gained notability as an actor and television personality.

The city mayor of Manila is the head of the executive branch of Manila's city government. The mayor holds office at Manila City Hall. Like all local government heads in the Philippines, the mayor is elected via popular vote, and may not be elected for a fourth consecutive term. In case of death, resignation or incapacity, the vice mayor becomes the mayor.