Isla Cardona, also known as Sor Isolina Ferré Island, is a small, uninhabited island located 1.30 nautical miles south of the mainland Puerto Rican shore across from Barrio Playa, on the west side of the entrance to the harbor of Ponce, Puerto Rico. The small island is considered part of barrio Playa. It is home to the 1889 Cardona Island Light, which is listed in the U.S. National Register of Historic Places. Together with Caja de Muertos, Gatas, Morrillito, Ratones, Isla del Frio, and Isla de Jueyes, Cardona is one of seven islands ascribed to the municipality of Ponce. The island gained notoriety in 2010 when the Puerto Rican Bird Society made it a target for the eradication of the black rat.

Ponce is a city and a municipality on the southern coast of Puerto Rico. The most populated city outside the San Juan metropolitan area, was founded on August 12, 1692 and is named after Juan Ponce de León y Loayza, the great-grandson of Spanish conquistador Juan Ponce de León. Ponce is often referred to as La Perla del Sur, La Ciudad Señorial, and La Ciudad de las Quenepas.