Islamic Cairo, or Medieval Cairo, officially Historic Cairo, refers mostly to the areas of Cairo, Egypt, that were built from the Muslim conquest in 641 CE until the city's modern expansion in the 19th century during Khedive Ismail's rule, namely: the central parts within the old walled city, the historic cemeteries, the area around the Citadel of Cairo, parts of Bulaq, and Old Cairo which dates back to Roman times and includes major Coptic Christian monuments.

The Amr ibn al-As Mosque is a mosque in Cairo, Egypt. Named after the Arab Muslim commander Amr ibn al-As, the mosque was originally built in 641–642 CE as the center of the newly founded capital of Egypt, Fustat. The original structure was the first mosque ever built in Egypt and one of the first in Africa. For 600 years, the mosque was also an important center of Islamic learning until al-Muizz's Al-Azhar Mosque in Islamic Cairo replaced it. Through the twentieth century, it was the fourth largest mosque in the Islamic world.