Isle La Motte is an island in Lake Champlain in northwestern Vermont, United States. At 7 mi (11 km) by 2 mi (3 km), it lies close to the place that the lake empties into the Richelieu River. It is incorporated as a New England town in Grand Isle County. Its population was 488 at the 2020 census.

Lake Champlain is a natural freshwater lake in North America. It mostly lies between the US states of New York and Vermont, but also extends north into the Canadian province of Quebec.