Isle of Palms is a city in Charleston County, South Carolina, United States. At the 2010 census, the population was 4,133. Isle of Palms is a barrier island on the South Carolina coast. The city is included within the Charleston-North Charleston-Summerville metropolitan area and the Charleston-North Charleston Urbanized Area. The town lies along a narrow strip of land, hugging the beach, separated from the mainland by the Intracoastal Waterway. It is a community of both vacation home owners and year-round residents, with large beachfront homes, resorts, and local restaurants. Beach volleyball is popular in the summer, and the "Windjammer" club hosts several tournaments throughout the year.

Charleston County is located in the U.S. state of South Carolina along the Atlantic coast. As of the 2020 census, the population was 408,235, making it the third-most populous county in South Carolina. Its county seat is Charleston. It is also the largest county in the state by total area, although Horry County has a larger land area. The county was created in 1800 by an act of the South Carolina State Legislature.