Ismael Mario Zambada García is a Mexican drug lord, co-founder and current top leader of the Sinaloa Cartel, an international crime syndicate based in Sinaloa. Before he assumed leadership of the entire cartel, he allegedly served as the logistical coordinator for its Guzmán-Zambada organization, which has overseen the trafficking of cocaine and heroin into Chicago and other US cities by aircraft, narcosubs, container ships, go-fast boats, fishing vessels, buses, rail cars, tractor trailers, and automobiles. As of early 2024, he has never been arrested or incarcerated and is the single last remaining fugitive of the List of Mexico's 37 most-wanted drug lords (2009).

A drug lord, drug baron, kingpin, or lord of drugs is a type of crime boss in charge of a drug trafficking network, organization, or enterprise.