Isolate and Medicate is the sixth studio album by South African rock band Seether. It was released on 1 July 2014 by The Bicycle Music Company, in association with Concord Music Group and Spinefarm Records. It is the first Seether album to be released on a vinyl LP.

Seether are a South African rock band founded in 1999 in Pretoria, Gauteng. The band originally performed under the name Saron Gas until 2002, when they moved to the United States and changed it to Seether to avoid confusion with the deadly chemical known as sarin gas. Lead vocalist and guitarist Shaun Morgan is the band's longest serving member, bassist Dale Stewart joined shortly after formation while drummer John Humphrey joined them for the band's second album. Since 2018, the band has been employing second guitarist Corey Lowery. Several notable guitarists like Corey's brother Clint and Troy McLawhorn have toured or recorded with the band, however, Shaun has recorded most guitar parts for the band's records.