Istedgade is a 1-kilometer straight street in the district of Vesterbro in the Danish capital, Copenhagen. It starts at Copenhagen Central Station and runs parallel to Vesterbrogade to Enghave Plads and Enghaveparken. From the station in the cheap hotel district, it runs through the porn, prostitution and drugs area to modern Vesterbro, where 1900s tenement style blocks have undergone significant modernisation. It is generally considered the heart of Vesterbro and was a main traffic artery until 2013 where the street had traffic reducing measures installed.

Vesterbro is one of the 15 administrative, statistical, and city tax districts (bydele) comprising the municipality of Copenhagen, Denmark. It covers an area of 3.76 km2 (1.45 sq mi), and has a population of 51,466 and a population density of 13,688 per km2.