Andrew Duggan was an American character actor of both film and television. Duggan was born in Franklin in Johnson County in south central Indiana. During World War II, he served in the United States Army 40th Special Services Company, led by actor Melvyn Douglas in the China Burma India Theater of World War II, his contact with Douglas led to his performing with Lucille Ball in the play Dreamgirl. Duggan developed a friendship with Broadway director Daniel Mann on a troopship when returning from the war. Duggan appeared on Broadway in The Rose Tattoo, Gently Does It, Anniversary Waltz, Fragile Fox, The Third Best Sport. Duggan appeared in some 70 films, including The Incredible Mr. Limpet with Don Knotts, in more than 140 television programs between 1949 and 1987, he was the main character in the Disney theme parks' Carousel of Progress and the singer of the accompanying song, The Best Time of Your Life, subsequently updated with new voices and songs in 1993. Duggan did voice-over work including voice-over for Ziebart's 1985 Clio Award-winning "Friend of the Family" television commercial.
In 1957, Duggan played a villain in the first episode of NBC's Wagon Train. That same year, Duggan was cast with Peter Brown and Bob Steele in the guest cast of the first episode of the ABC/Warner Brothers series, Colt.45, starring Wayde Preston as Christopher Colt, an undercover agent and pistol salesman in the Old West. In the opening episode, "The Peacemaker" or "Judgment Day", Duggan plays Jim Rexford. Duggan had a recurring role as General Ed Britt in the second and third seasons of the ABC war series, Twelve O'Clock High, he appeared on the NBC westerns Jefferson Drum, The Big Valley and was in the pilot episodes of both NBC's The Restless Gun and CBS's Hawaii Five-O, as a former prisoner and an intelligence agent, respectively. In 1959, Duggan was contracted to Warner Bros. where he was cast in ABC's Bourbon Street Beat, in which he portrayed Cal Calhoun, the head of a New Orleans detective agency. When Bourbon Street Beat was canceled after a single season, the two other detectives in the series were transferred to other Warner Bros. detective series: Van Williams as Kenny Madison remained in the same time slot with a new series Surfside 6.
Richard Long as Rex Randolph assumed ailing Roger Smith's position on the hit series 77 Sunset Strip. In 1962, Duggan starred in the 26-week ABC situation comedy, Room for One More, with co-stars Peggy McCay, Ronnie Dapo, Tim Rooney, a son of Mickey Rooney; the series is about a couple with two children. During this time Duggan guest starred in several Warner Bros. Television series and appeared in several Warner Bros. films, including The Chapman Report and Merrill's Marauders and the television pilot FBI Code 98. He provide narration for several Warner Bros. film trailers. Duggan guest starred in numerous television series in the 1960s, including the western Tombstone Territory in the episode "The Epitaph", he appeared as an incorrigible criminal trying to gain amnesty in the 1962 episode "Sunday" of the ABC/WB series, starring John Russell. In 1963, he guest starred on The Dakotas. Duggan was cast on Jack Palance's ABC circus drama, The Greatest Show on Earth and the NBC medical drama about psychiatry, The Eleventh Hour in the role of Carl Quincy in the 1963 episode entitled "Four Feet in the Morning".
He played the over-protective Police Chief Dixon in the 1963 spring break film Palm Springs Weekend, in which he attempts to prevent his daughter from seeing student Jim Munroe. In 1965, he appeared on The Fugitive. Duggan had recurring roles on CBS's 90-minute western, Cimarron Strip, on ABC's The Great Adventure, he had roles in the 1964 film, Seven Days in May, played the U. S. President and an imposter in the 1967 film, In Like Flint. Duggan was cast in a 1964 episode of The Alfred Hitchcock Hour entitled "The McGregor Affair". In this segment, he portrays a man who determines a way to get rid of his drunken wife, only to regret what he had done and become a victim of the same fate he had planned for his wife. In 1966 he played Father Michael in "The Eighth Day" an episode of Bob Hope Presents the Chrysler Theatre. In 1966, Duggan appeared on F Troop as Major Chester Winster, in the episode: "The New I. G.". He played Brigadier/Major General Ed Britt in the ABC TV series 12 O'clock High. Duggan portrayed the patriarch in a 1968–1970 series called Lancer, in which he played cattle baron Murdoch Lancer, while James Stacy portrayed Lancer's gunfighter son, Johnny Madrid, son of Maria, Murdoch's second wife.
Some six years earlier and Duggan had appeared together, along with Joan Caulfield, in the series finale, "Showdown at Oxbend", a classic drama of the fight between cattlemen and sheepherders, on the ABC/WB western series, with Clint Walker in the title role. Wayne Maunder portrayed the older son, Scott Lancer, educated in Boston. In real life Maunder had been reared in Maine. Lancer lasted for only fifty-one episodes, but critics cited the scripts and performances as excellent. Paul Brinegar co-starred as Jelly Hoskins, having played a similar role of "Wishbone" on CBS's earlier western series Rawhide, with Eric Fleming and Clint Eastwood. Duggan played the patriarch in the television film The Homecoming: A Christmas Story; the part of John Walton in the series it inspired, The Waltons, was played by Ralph Waite. In 1973, Duggan had a cameo appearance in the blaxploitation film Black Caesar. In 1975, he appeared as FBI Inspector Ryder in the NB
In biology and genetics, a mutant is an organism or a new genetic character arising or resulting from an instance of mutation, an alteration of the DNA sequence of the genome or chromosome of an organism. The term mutant is applied to a virus with an alteration in its nucleotide sequence whose genome is RNA, rather than DNA. In multicellular eukaryotes, a DNA sequence may be altered in an individual somatic cell that gives rise to a mutant somatic cell lineage as happens in cancer progression. In eukaryotes, alteration of a mitochondrial or plastid DNA sequence may give rise to a mutant lineage, inherited separately from mutant genotypes in the nuclear genome; the natural occurrence of genetic mutations is integral to the process of evolution. The study of mutants is an integral part of biology. Mutants arise by mutations occurring in pre-existing genomes as a result of errors of DNA replication or errors of DNA repair. Errors of replication involve translesion synthesis by a DNA polymerse when it encounters and bypasses a damaged base in the template strand.
A DNA damage is an abnormal chemical structure in DNA, such as a strand break or an oxidized base, whereas a mutation, by contrast, is a change in the sequence of standard base pairs. Errors of repair occur; the DNA repair process microhomology-mediated end joining is error-prone. Although not all mutations have a noticeable phenotypic effect, the common usage of the word "mutant" is a pejorative term only used for genetically or phenotypically noticeable mutations. People used the word "sport" to refer to abnormal specimens; the scientific usage is broader. Mutants should not be confused with organisms born with developmental abnormalities, which are caused by errors during morphogenesis. In a developmental abnormality, the DNA of the organism is unchanged and the abnormality cannot be passed on to progeny. Conjoined twins are the result of developmental abnormalities. Chemicals that cause developmental abnormalities are called teratogens. Chemicals that induce mutations are called mutagens. Most mutagens are considered to be carcinogens.
Mutations are distinctly different from epigenetic alterations, although they share some common features. Both arise as a chromosomal alteration that can be replicated and passed on to subsequent cell generations. Both, when occurring within a gene, may silence expression of the gene. Whereas mutant cell lineages arise as a change in the sequence of standard bases, epigenetically altered cell lineages retain the sequence of standard bases but have gene sequences with changed levels of expression that can be passed down to subsequent cell generations. Epigenetic alterations include methylation of CpG islands of a gene promoter as well as specific chromatin histone modifications. Faulty repair of chromosomes at sites of DNA damage can give rise both to mutant cell lineages and/or epigenetically altered cell lineages. Evolution Genetic engineering Genetically modified organism Mutants of fiction Mutationism Synthetic lethality Synthetic viability Antennapedia mutant
God Told Me To
God Told Me To is a 1976 science fiction/horror film written and directed by Larry Cohen. Like many of Cohen's films, it is shot on location in New York City and incorporates aspects of the police procedural. In New York City, a gunman perched atop a water tower opens fire with a.22 caliber rifle on the crowded streets below, randomly killing fifteen pedestrians. Peter Nicholas, a devout Catholic NYPD detective, climbs the tower to talk to the sniper. Before jumping to his death, the gunman tells Nicholas. Although traumatized by the attack, Nicholas investigates a series of unpremeditated murders that follow: a mass stabbing at a supermarket, a mass shooting by a police officer at a St. Patrick's Day parade, a man who murders his wife and children, they have all been committed by a variety of unconnected normal assailants who claim that God told them to kill. Nicholas learns; when Nicholas visits Phillips' address, Phillips' mother assaults Nicholas with a knife, but she dies during the attack by falling down a flight of stairs.
She turns out to have once claimed she was abducted by aliens. Nicholas' superiors refuse to acknowledge a religious motivation for the murders and suspend him, so he leaks this story to the press, causing a panic. A group of men, members of a religious cult, are aware that their leader, Bernard Phillips, is influencing the murderers as he contacts and controls them via psychic powers and as he has informed them of each impending atrocity. Phillips has one of the members invite Nicholas to join them, but when Nicholas asks whether the follower knows about Phillips' mother, the follower suffers convulsions and drops dead. Another cult member attempts to kill Nicholas by pushing him in front of a subway train, but when he fails, Nicholas forces him to take him to Phillips, who isolates himself in a fiery furnace room deep underground. After delivering Nicholas, the follower decapitates himself using an elevator. A brief meeting convinces Nicholas that he himself is special and that Phillips does not kill him as he needs him for some purpose.
By researching his own adoption records, Nicholas finds an old woman who seems to be his birth mother. She explains that she gave up her out-of-wedlock child after she was impregnated by a strange orb of light while she walked home from the New York Worlds Fair in 1941; the meeting distresses both of them, Nicholas is wracked with doubt over who or what he is. He confronts Phillips one last time and discovers the truth: both he and Phillips are the result of "virgin births" caused by a mysterious extraterrestrial "entity of light" with psychic or supernatural powers and advanced spacecraft technology. Nicholas' human genes are dominant, why he is unaware of his true nature, while Phillips is more like their unseen progenitor. Phillips reveals himself to be a hermaphrodite who wishes to spawn a new species with his "brother." Nicholas refuses and attacks Phillips, who uses his powers to destroy the building they are in and thereby commit suicide. Nicholas is arrested for the murder of Phillips.
As he is led into court by police, a news reporter asks him. He responds, "God told me to." Nicholas is committed to the Matteawan State Hospital for the Criminally Insane. Tony Lo Bianco as Det. Lt. Peter J. Nicholas Deborah Raffin as Casey Forster Sandy Dennis as Martha Nicholas Sylvia Sidney as Elizabeth Mullin Sam Levene as Everett Lukas Robert Drivas as David Morten Mike Kellin as Deputy Police Commissioner Richard Lynch as Bernard Phillips Sammy Williams as Harold Gorman Harry Bellaver as Cookie Andy Kaufman as Police Officer Cohen was inspired to make the film by the Bible, he thought God in the Bible was one of the most violent characters in literature. He was influenced by the book Chariots of the Gods; the film was financed by Daniel Blatt. They were credited as executive producers but Cohen says when they saw the finished film they insisted their names be taken off it. Robert Forster was cast in the lead role. A few days into filming he and Cohen had a falling out and Forster quit. Forster said Cohen "was one of those guys who yelled a lot on the set, I said, "Hey, this isn't for me.
Let me out of here." We parted friendly and all that." Cohen replaced him with Tony Lo Bianco, in Cohen's play The Nature of the Crime. Bernard Herrmann, who had scored Cohen's earlier film It's Alive, was assigned to score God Told Me To as well, Cohen claims on the DVD commentary track that Herrmann saw the first cut of the film after completing the recording sessions for his score to Taxi Driver and made notes on how he believed it could be scored. However, within the next 15 hours, Herrmann died. Cohen asked composer Miklos Rozsa to score the film. Rozsa turned it down, saying "God told me not to". Frank Cordell composed the score heard in the released version of God Told Me To, both it and Taxi Driver were dedicated to Herrmann. The'alien abduction' sequence, where a naked woman is drawn up into the cavernous interior of an extraterrestrial spacecraft, features generic stock model footage from Gerry Anderson's science fiction TV series Space: 1999. Andy Kaufman appears as a possessed policeman who goes on a shooting rampage at the Saint Patrick's Day parade — it was Kaufman's first role in any film, the same footage was used for the finale of a documentary called The Passion of Andy Kaufman, in a segment called "Thus Spake Zarathustra", with music by Eumir Deodato.
Sylvia Sidney appears as Detective Nicholas's long-lost, traumatized mothe
Warner Bros. Entertainment Inc. referred to as Warner Bros. and abbreviated as WB, is an American entertainment company headquartered in Burbank, California and a subsidiary of AT&T's WarnerMedia. Founded in 1923, it has operations in film and video games and is one of the "Big Five" major American film studios, as well as a member of the Motion Picture Association of America; the company's name originated from the four founding Warner brothers: Harry, Albert and Jack Warner. Harry and Sam emigrated as young children with their parents to Canada from Krasnosielc, Poland. Jack, the youngest brother, was born in Ontario; the three elder brothers began in the movie theater business, having acquired a movie projector with which they showed films in the mining towns of Pennsylvania and Ohio. In the beginning and Albert Warner invested $150 to present Life of an American Fireman and The Great Train Robbery, they opened their first theater, the Cascade, in New Castle, Pennsylvania, in 1903. When the original building was in danger of being demolished, the modern Warner Bros. called the current building owners, arranged to save it.
The owners noted people across the country had asked them to protect it for its historical significance. In 1904, the Warners founded the Pittsburgh-based Duquesne Amusement & Supply Company, to distribute films. In 1912, Harry Warner hired. By the time of World War I they had begun producing films. In 1918 they opened the first Warner Brothers Studio on Sunset Boulevard in Hollywood. Sam and Jack produced the pictures, while Harry and Albert, along with their auditor and now controller Chase, handled finance and distribution in New York City. During World War I their first nationally syndicated film, My Four Years in Germany, based on a popular book by former ambassador James W. Gerard, was released. On April 4, 1923, with help from money loaned to Harry by his banker Motley Flint, they formally incorporated as Warner Bros. Pictures, Incorporated; the first important deal was the acquisition of the rights to Avery Hopwood's 1919 Broadway play, The Gold Diggers, from theatrical impresario David Belasco.
However, Rin Tin Tin, a dog brought from France after World War I by an American soldier, established their reputation. Rin Tin Tin debuted in the feature; the movie was so successful. Rin Tin Tin became the studio's top star. Jack nicknamed him "The Mortgage Lifter" and the success boosted Darryl F. Zanuck's career. Zanuck became a top producer and between 1928 and 1933 served as Jack's right-hand man and executive producer, with responsibilities including day-to-day film production. More success came. Lubitsch's film The Marriage Circle was the studio's most successful film of 1924, was on The New York Times best list for that year. Despite the success of Rin Tin Tin and Lubitsch, Warner's remained a lesser studio. Sam and Jack decided to offer Broadway actor John Barrymore the lead role in Beau Brummel; the film was so successful. By the end of 1924, Warner Bros. was arguably Hollywood's most successful independent studio, where it competed with "The Big Three" Studios. As a result, Harry Warner—while speaking at a convention of 1,500 independent exhibitors in Milwaukee, Wisconsin—was able to convince the filmmakers to spend $500,000 in newspaper advertising, Harry saw this as an opportunity to establish theaters in cities such as New York and Los Angeles.
As the studio prospered, it gained backing from Wall Street, in 1924 Goldman Sachs arranged a major loan. With this new money, the Warners bought the pioneer Vitagraph Company which had a nationwide distribution system. In 1925, Warners' experimented in radio, establishing a successful radio station, KFWB, in Los Angeles. Warner Bros. was a pioneer of films with synchronized sound. In 1925, at Sam's urging, Warner's agreed to add this feature to their productions. By February 1926, the studio reported a net loss of $333,413. After a long period denying Sam's request for sound, Harry agreed to change, as long as the studio's use of synchronized sound was for background music purposes only; the Warners signed a contract with the sound engineer company Western Electric and established Vitaphone. In 1926, Vitaphone began making films with music and effects tracks, most notably, in the feature Don Juan starring John Barrymore; the film was silent. To hype Don Juan's release, Harry acquired the large Piccadilly Theater in Manhattan, New York City, renamed it Warners' Theatre.
Don Juan premiered at the Warners' Theatre in New York on August 6, 1926. Throughout the early history of film distribution, theater owners hired orchestras to attend film showings, where they provided soundtracks. Through Vitaphone, Warner Bros. produced eight shorts in 1926. Many film production companies questioned the necessity. Don Juan did not recoup its production cost and Lubitsch left for MGM. By April 1927, the Big Five studios had ruined Warner's, Western Electric renewed Warner's Vit
Guy Harry Stockwell was an American actor who appeared in nearly 30 movies and 250 television series episodes. Stockwell was born in New York City, the stepson of Elizabeth Margaret Veronica, son of Elizabeth "Betty" Stockwell and Harry Stockwell, an actor and singer, his younger brother is actor Dean Stockwell. Stockwell began his acting career on the stage, working in the Broadway productions Innocent Voyage and Chicken Every Sunday; that affinity for the stage would inspire him to become a co-founder of the Los Angeles Art Theater. He went on to hold the recurring role of Chris Parker from 1961 to 1962 in twenty-six episodes of the ABC series Adventures in Paradise, starring Gardner McKay as the skipper of a sailing vessel set in the South Pacific. Stockwell was cast in episodes of The Roaring 20s, Perry Mason, Quincy, M. E. Simon & Simon, Knight Rider, Tales of the Gold Monkey, The Eddie Capra Mysteries, Magnum, P. I. Murder, She Wrote, Quantum Leap, Land of the Giants, Tombstone Territory, Combat!, The Richard Boone Show, The Virginian and Return to Peyton Place, He had important roles in several major motion pictures including The War Lord, The Plainsman, Beau Geste, The Monitors, It's Alive and Santa Sangre.
Stockwell suffered from diabetes in years and died of its complications. He had three children. Guy Stockwell on IMDb Guy Stockwell at the Internet Broadway Database Guy Stockwell at Find a Grave
John P. Ryan
John Patrick Ryan was an American actor, best known for his role as Warden Ranken in the 1985 film Runaway Train. The son of Irish immigrant parents, Ryan graduated from Rice High School and studied English at the City College of New York, he was a lifetime member of The Actors Studio. Ryan died from a stroke in Los Angeles, California, at the age of 70, he was survived by two daughters. Kojak as Peter Ibbotson Death Scream as Detective Dave Lambert Buck Rogers in the 25th Century as Kurt Belzack M*A*S*H as Major Van Zandt Miss Lonelyhearts as Peter Doyle Simon & Simon as Stewart Crawford Cagney & Lacey as Philip Corrigan Miami Vice as Jake Manning John P. Ryan on IMDb John P. Ryan at the Internet Broadway Database John P. Ryan at the Internet Off-Broadway Database John P. Ryan at AllMovie John P. Ryan at Find a Grave
Los Angeles the City of Los Angeles and known by its initials L. A. is the most populous city in California, the second most populous city in the United States, after New York City, the third most populous city in North America. With an estimated population of four million, Los Angeles is the cultural and commercial center of Southern California; the city is known for its Mediterranean climate, ethnic diversity and the entertainment industry, its sprawling metropolis. Los Angeles is the largest city on the West Coast of North America. Los Angeles is in a large basin bounded by the Pacific Ocean on one side and by mountains as high as 10,000 feet on the other; the city proper, which covers about 469 square miles, is the seat of Los Angeles County, the most populated county in the country. Los Angeles is the principal city of the Los Angeles metropolitan area, the second largest in the United States after that of New York City, with a population of 13.1 million. It is part of the Los Angeles-Long Beach combined statistical area the nation's second most populous area with a 2015 estimated population of 18.7 million.
Los Angeles is one of the most substantial economic engines within the United States, with a diverse economy in a broad range of professional and cultural fields. Los Angeles is famous as the home of Hollywood, a major center of the world entertainment industry. A global city, it has been ranked 6th in the Global Cities Index and 9th in the Global Economic Power Index; the Los Angeles metropolitan area has a gross metropolitan product of $1.044 trillion, making it the third-largest in the world, after the Tokyo and New York metropolitan areas. Los Angeles hosted the 1932 and 1984 Summer Olympics and will host the event for a third time in 2028; the city hosted the Miss Universe pageant twice, in 1990 and 2006, was one of 9 American cities to host the 1994 FIFA men's soccer World Cup and one of 8 to host the 1999 FIFA women's soccer World Cup, hosting the final match for both tournaments. Home to the Chumash and Tongva, Los Angeles was claimed by Juan Rodríguez Cabrillo for Spain in 1542 along with the rest of what would become Alta California.
The city was founded on September 4, 1781, by Spanish governor Felipe de Neve. It became a part of Mexico in 1821 following the Mexican War of Independence. In 1848, at the end of the Mexican–American War, Los Angeles and the rest of California were purchased as part of the Treaty of Guadalupe Hidalgo, becoming part of the United States. Los Angeles was incorporated as a municipality on April 4, 1850, five months before California achieved statehood; the discovery of oil in the 1890s brought rapid growth to the city. The completion of the Los Angeles Aqueduct in 1913, delivering water from Eastern California assured the city's continued rapid growth; the Los Angeles coastal area was settled by the Chumash tribes. A Gabrieleño settlement in the area was called iyáangẚ, meaning "poison oak place". Maritime explorer Juan Rodríguez Cabrillo claimed the area of southern California for the Spanish Empire in 1542 while on an official military exploring expedition moving north along the Pacific coast from earlier colonizing bases of New Spain in Central and South America.
Gaspar de Portolà and Franciscan missionary Juan Crespí, reached the present site of Los Angeles on August 2, 1769. In 1771, Franciscan friar Junípero Serra directed the building of the Mission San Gabriel Arcángel, the first mission in the area. On September 4, 1781, a group of forty-four settlers known as "Los Pobladores" founded the pueblo they called El Pueblo de Nuestra Señora la Reina de los Ángeles,'The Town of Our Lady the Queen of the Angels'; the present-day city has the largest Roman Catholic Archdiocese in the United States. Two-thirds of the Mexican or settlers were mestizo or mulatto, a mixture of African and European ancestry; the settlement remained a small ranch town for decades, but by 1820, the population had increased to about 650 residents. Today, the pueblo is commemorated in the historic district of Los Angeles Pueblo Plaza and Olvera Street, the oldest part of Los Angeles. New Spain achieved its independence from the Spanish Empire in 1821, the pueblo continued as a part of Mexico.
During Mexican rule, Governor Pío Pico made Los Angeles Alta California's regional capital. Mexican rule ended during the Mexican–American War: Americans took control from the Californios after a series of battles, culminating with the signing of the Treaty of Cahuenga on January 13, 1847. Railroads arrived with the completion of the transcontinental Southern Pacific line to Los Angeles in 1876 and the Santa Fe Railroad in 1885. Petroleum was discovered in the city and surrounding area in 1892, by 1923, the discoveries had helped California become the country's largest oil producer, accounting for about one-quarter of the world's petroleum output. By 1900, the population had grown to more than 102,000; the completion of the Los Angeles Aqueduct in 1913, under the supervision of William Mulholland, assured the continued growth of the city. Due to clauses in the city's charter that prevented the City of Los Angeles from selling or providing water from the aqueduct to any area outside its borders, many adjacent city and communities became compelled to annex themselves into Los Angeles.
Los Angeles created the first municipal zoning ordinance in the United States. On September 14, 1908, the Los Angeles City Council promulgated residential and industrial land use zones; the new ordinance established three residential zones of a single type, where industrial uses were