The Itakura clan is a Japanese clan which came to prominence during the Sengoku period. The family claimed descent from Shibukawa Yoshiaki, the son of Ashikaga Yasuuji, a relative of the Ashikaga shōguns. Over time, the clan evolved into several branches which were daimyō, ruling the Bitchū-Matsuyama, Niwase, Fukushima, and Annaka Domains.

Bitchū-Matsuyama Domain was a feudal domain under the Tokugawa shogunate of Edo period Japan, in what is now western Okayama Prefecture. It controlled most of central Bitchū Province and was centered around Bitchū Matsuyama Castle. It was ruled in its latter history by a branch of the Itakura clan. Following the Meiji restoration, it was briefly renamed Takahashi Domain . It was dissolved in the abolition of the han system in 1871 and is now part of Okayama Prefecture.