The Italian Wars were a series of conflicts fought between 1494 and 1559, mostly in the Italian Peninsula, but later expanding into Flanders, the Rhineland and Mediterranean Sea. The primary belligerents were the Valois kings of France, and their Habsburg opponents in the Holy Roman Empire and Spain. At different points, various Italian states participated in the war, some on both sides, with limited involvement from England and the Ottoman Empire.

The Duchy of Milan was a state in Northern Italy, created in 1395 by Gian Galeazzo Visconti, then the lord of Milan, and a member of the important Visconti family, which had been ruling the city since 1277.