The Italian Wars were a series of conflicts fought between 1494 and 1559, mostly in the Italian Peninsula, but later expanding into Flanders, the Rhineland and Mediterranean Sea. The primary belligerents were the Valois kings of France, and their Habsburg opponents in the Holy Roman Empire and Spain. At different points, various Italian states participated in the war, some on both sides, with limited involvement from England and the Ottoman Empire.

The Kingdom of France is the historiographical name or umbrella term given to various political entities of France in the medieval and early modern period. It was one of the most powerful states in Europe since the High Middle Ages. It was also an early colonial power, with colonies in Asia and Africa, and the largest being New France in North America centred around the Great Lakes.