Italy competed at the 2012 Summer Olympics in London, from 27 July to 12 August 2012. This nation has competed at every Summer Olympic Games in the modern era, except for the 1904 Summer Olympics in St. Louis. The Italian National Olympic Committee sent the nation's smallest delegation to the Games since the 1988 Summer Olympics in Seoul. A total of 285 athletes, 162 men and 123 women, competed in 22 sports.

At the 2012 Summer Olympics Parade of Nations of the 2012 London Olympics, athletes and officials from each participating country paraded into the Olympic Stadium preceded by their national flag to the sound of iconic British modern music. Each flag bearer was chosen by each nation's National Olympic Committee or by the delegation of athletes.