Itanium is a discontinued family of 64-bit Intel microprocessors that implement the Intel Itanium architecture. The Itanium architecture originated at Hewlett-Packard (HP), and was later jointly developed by HP and Intel. Launched in June 2001, Intel initially marketed the processors for enterprise servers and high-performance computing systems. In the concept phase, engineers said "we could run circles around PowerPC...we could kill the x86." Early predictions were that IA-64 would expand to the lower-end servers, supplanting Xeon, and eventually penetrate into the personal computers, eventually to supplant reduced instruction set computing (RISC) and complex instruction set computing (CISC) architectures for all general-purpose applications.

In computer architecture, 64-bit integers, memory addresses, or other data units are those that are 64 bits wide. Also, 64-bit central processing units (CPU) and arithmetic logic units (ALU) are those that are based on processor registers, address buses, or data buses of that size. A computer that uses such a processor is a 64-bit computer.