Itasca County is a county located in the Iron Range region of the U.S. state of Minnesota. As of the 2020 census, the population was 45,014. Its county seat is Grand Rapids. The county is named after Lake Itasca, which is in turn a shortened version of the Latin words veritas caput, meaning 'truth' and 'head', a reference to the source of the Mississippi River. Portions of the Bois Forte and Leech Lake Indian reservations are in the county.

Grand Rapids is a city in Itasca County, Minnesota, United States, and it is the county seat. The population was 11,126 at the 2020 census. The city is named for the 3.5-mile (5.6 km) long rapids in the Mississippi River which was the uppermost limit of practical steamboat travel during the late 19th century. Today the rapids are hidden below the dam of UPM Paper Company.