Iyo-Saijō Station is a passenger railway station located in the city of Saijō, Ehime Prefecture, Japan. It is operated by JR Shikoku and has the station number "Y31". It is the main station of the city of Saijō and a major terminal on the Yosan Line with many train services beginning or ending here.

The Yosan Line is the principal railway line on the island of Shikoku in Japan, connecting the major cities of Shikoku, and via the Honshi-Bisan Line, with Honshu. It is operated by the Shikoku Railway Company, and is aligned approximately parallel with the Inland Sea coast, connecting the prefectural capitals of Takamatsu and Matsuyama and continuing on to Uwajima. The name of the line comes from Iyo (伊予) and Sanuki (讃岐), the old names of Ehime and Kagawa, respectively.