Isobel Katherine Stevens, M.D. is a fictional character from the medical drama television series Grey's Anatomy, which airs on the American Broadcasting Company (ABC) in the United States. The character was created by series producer Shonda Rhimes, and was portrayed by actress Katherine Heigl from 2005 to 2010. Introduced as a surgical intern at the fictional Seattle Grace Hospital, Izzie worked her way up to resident level, while her relationships with her colleagues Meredith Grey, Cristina Yang, Alex Karev and George O'Malley formed a focal point of the series.

Grey's Anatomy is an American medical drama television series focusing on the personal and professional lives of surgical interns, residents, and attendings at the fictional Seattle Grace Hospital, later named the Grey Sloan Memorial Hospital. The series premiered on March 27, 2005, on ABC as a mid-season replacement. The show's title is an allusion to Gray's Anatomy, a classic human anatomy textbook. Writer Shonda Rhimes developed the pilot and served as showrunner, head writer, and executive producer until stepping down in 2015. Set in Seattle, Washington, the series is filmed primarily in Los Angeles, California, and Vancouver, British Columbia.