James Gettys McGready Ramsey was an American historian, physician, planter, slave owner, and businessman, active primarily in East Tennessee during the nineteenth century. Ramsey is perhaps best known for his book, The Annals of Tennessee to the End of the Eighteenth Century, a seminal work documenting the state's frontier and early statehood periods. Ramsey was also a major advocate for development in East Tennessee, leading efforts to bring railroad access to the region, and helping to organize the region's first medical society.

The Watauga Association was a semi-autonomous government created in 1772 by frontier settlers living along the Watauga River in what is now Elizabethton, Tennessee. Although it lasted only a few years, the Watauga Association provided a basis for what later developed into the state of Tennessee and likely influenced other western frontier governments in the trans-Appalachian region. North Carolina annexed the Watauga settlement area, by then known as the Washington District, in November 1776. Within a year, the area was placed under a county government, becoming Washington County, North Carolina, in November 1777. This area covers the present day Washington County, Carter County, and other areas now located in the northeast part of the state of Tennessee.