Jackson County is located in the Arkansas Delta in the U.S. state of Arkansas. The county is named for Andrew Jackson, a national hero during the War of 1812. By the county's formation in 1829, Jackson had become the seventh President of the United States. Jackson County is home to seven incorporated towns and four incorporated cities, including Newport, the largest city and county seat. The county is also the site of numerous unincorporated communities and ghost towns. Occupying 633.94 square miles (164,190 ha), Jackson County is the 41st largest county of the 75 in Arkansas. As of the 2020 Census, the county's population was 16,755. Based on population, the county is the 44th-largest county in Arkansas. Although terrain rises in the west, most of Jackson County is within the Arkansas Delta, characterized by largely flat terrain with fertile soils. Historically covered in forest, bayous and swamps, the area was cleared for agriculture by early settlers. It is drained by the White River.

The Arkansas Delta is one of the six natural regions of the state of Arkansas. Willard B. Gatewood Jr., author of The Arkansas Delta: Land of Paradox, says that rich cotton lands of the Arkansas Delta make that area "The Deepest of the Deep South."