Jackson County is a county located in the U.S. state of Illinois with a population of 52,974 at the 2020 census. Its county seat is Murphysboro, and its most populous city is Carbondale, home to the main campus of Southern Illinois University. The county was incorporated on January 10, 1816, and named for Andrew Jackson. The community of Brownsville served as the fledgling county's first seat.

Murphysboro is a city in and the county seat of Jackson County, Illinois, United States. The population was 7,093 at the 2020 census. The city is part of the Metro Lakeland area. The mayor of Murphysboro is Will Stephens. The government consists of the mayor and 10 city aldermen.