Jackson County is located in the U.S. state of Michigan. The population of the county was 160,366 as of the 2020 Census. Its seat of government is the city of Jackson. The county was set off in 1829 and organized in 1832. It is named for U.S. President Andrew Jackson and considered to be one of Michigan's "Cabinet counties", named for members of Jackson's Cabinet.

Jackson is the only city in, and seat of government of, Jackson County in the U.S. state of Michigan. As of the 2020 census, the city population was 31,309. Located along Interstate 94 and U.S. Route 127, it is approximately 40 miles (64 km) west of Ann Arbor and 35 miles (56 km) south of Lansing. Jackson is the core city of the Jackson Metropolitan Statistical Area, which includes all of Jackson County and has a population of 160,248.