Jackson County is a county located in the U.S. state of Mississippi. As of the 2020 census, the population was 143,252, making it the fifth-most populous county in Mississippi. Its county seat is Pascagoula. The county was named for Andrew Jackson, general in the United States Army and afterward President of the United States.

Pascagoula is a city in Jackson County, Mississippi, United States. It is the principal city of the Pascagoula metropolitan area, and is part of the Gulfport–Biloxi–Pascagoula Combined Statistical Area and the Gulfport-Biloxi metropolitan area. The population was 22,392 at the 2010 census, down from 26,200 at the 2000 census. In 2019 the population was 21,699. It is the county seat of Jackson County.