Jacobabad District is a district in the province of Sindh, Pakistan. According to 2023 Census population of Jacobabad District is 1,174,097 It is located in the north of Sindh, by the provincial boundary with Balochistan. Its headquarters is the town of Jacobabad, which was founded by General John Jacob in 1847.

Jacobabad is a city in Sindh, Pakistan, serving as both the capital city of Jacobabad District and the administrative centre of Jacobabad Taluka, an administrative subdivision of the district. The city itself is subdivided into eight Union Councils. Sitting far to the northwest of the province, near the provincial boundaries of Sindh and Balochistan, Jacobabad became a city on the site of an existing village (Khangarh), and is crossed by the Pakistan Railways and many main roads of the province. It is the 43rd most populous city in Pakistan.