Jacobs Creek is a 33.4-mile-long (53.8 km) tributary of the Youghiogheny River beginning in Acme, Pennsylvania and draining at its mouth in the town of Jacobs Creek into the Youghiogheny River. Jacobs Creek is the southwestern border of Westmoreland County and the northwestern border of Fayette County. The area was a major producer of rye whiskey in the decades before Prohibition.

Jacob's Creek Bridge was the first iron-chain suspension bridge built in the United States. Designed by James Finley, a local judge and inventor, it spanned Jacob's Creek, just south of Mount Pleasant, Pennsylvania. Nothing of the bridge is thought to remain, but an area on the north side of Jacob's Creek – where Route 819 crosses – is still called "Iron Bridge."