Jacobs Creek is a 33.4-mile-long (53.8 km) tributary of the Youghiogheny River beginning in Acme, Pennsylvania and draining at its mouth in the town of Jacobs Creek into the Youghiogheny River. Jacobs Creek is the southwestern border of Westmoreland County and the northwestern border of Fayette County. The area was a major producer of rye whiskey in the decades before Prohibition.

The Youghiogheny River, or the Yough for short, is a 134-mile-long (216 km) tributary of the Monongahela River in West Virginia, Maryland, and Pennsylvania. It drains an area on the west side of the Allegheny Mountains northward into Pennsylvania, providing a small watershed in extreme western Maryland into the tributaries of the Mississippi River. Youghiogheny is a Lenape word meaning "a stream flowing in a contrary direction".