The James A. Farley Building is a mixed-use structure in Midtown Manhattan, New York City, which formerly served as the city's main United States Postal Service (USPS) branch. Designed by McKim, Mead & White in the Beaux-Arts style, the structure was built between 1911 and 1914, with an annex constructed between 1932 and 1935. The Farley Building, at 421 Eighth Avenue between 31st Street and 33rd Street in Midtown Manhattan, faces Pennsylvania Station and Madison Square Garden to the east.

Midtown Manhattan is the central portion of the New York City borough of Manhattan and serves as the city's primary central business district. Midtown is home to some of the city's most prominent buildings, including the Empire State Building, the Chrysler Building, the Hudson Yards Redevelopment Project, the headquarters of the United Nations, Grand Central Terminal, and Rockefeller Center, as well as several prominent tourist destinations including Broadway, Times Square, and Koreatown. Penn Station in Midtown Manhattan is the busiest transportation hub in the Western Hemisphere.