James Anthony Griffin is an American prelate of the Roman Catholic Church. Griffin served as bishop of the Diocese of Columbus in Ohio from 1983 to 2004. He previously served as an auxiliary bishop of the Diocese of Cleveland in Ohio from 1979 to 1983.

The Diocese of Columbus is a Latin Church ecclesiastical territory, or diocese, of the Catholic Church covering 23 counties in central Ohio in the United States. It is a suffragan diocese in the ecclesiastical province of the metropolitan Archdiocese of Cincinnati.