The James B. Duke House is a mansion at 1 East 78th Street, on the northeast corner of Fifth Avenue, on the Upper East Side of Manhattan in New York City. The building was designed by Horace Trumbauer, who drew heavily upon the design of Château Labottière in Bordeaux. Constructed between 1909 and 1912 as a private residence for businessman James Buchanan Duke and his family, the building has housed the New York University (NYU)'s Institute of Fine Arts since 1959.

Horace Trumbauer was a prominent American architect of the Gilded Age, known for designing residential manors for the wealthy. Later in his career he also designed hotels, office buildings, and much of the campus of Duke University.