James Edwin Webb was an American government official who served as Undersecretary of State from 1949 to 1952. He was the second Administrator of NASA from February 14, 1961, to October 7, 1968. Webb led NASA from the beginning of the Kennedy administration through the end of the Johnson administration, thus overseeing each of the critical first crewed missions throughout the Mercury and Gemini programs until days before the launch of the first Apollo mission. He also dealt with the Apollo 1 fire.

The administrator of the National Aeronautics and Space Administration is the highest-ranking official of NASA, the national space agency of the United States. The administrator is NASA's chief decision maker, responsible for providing clarity to the agency's vision and serving as a source of internal leadership within NASA. The office holder also has an important place within United States space policy, and is assisted by a deputy administrator.