James Francis Byrnes was an American judge and politician from South Carolina. A member of the Democratic Party, he served in the U.S. Congress and on the U.S. Supreme Court, as well as in the executive branch, most prominently as the 49th U.S. Secretary of State under President Harry S. Truman. Byrnes was also the 104th governor of South Carolina, making him one of the very few politicians to have served in the highest levels of all three branches of the American federal government while also being active in state government.

The 1944 Democratic National Convention was held at the Chicago Stadium in Chicago, Illinois from July 19 to July 21, 1944. The convention resulted in the nomination of President Franklin D. Roosevelt for an unprecedented fourth term. Senator Harry S. Truman of Missouri was nominated for vice president. Including Roosevelt's nomination for the vice-presidency in 1920, it was the fifth time Roosevelt had been nominated on a national ticket. The keynote address was given by Governor Robert S. Kerr of Oklahoma, in which he "gave tribute to Roosevelt's war leadership and New Deal policies."