James Gillespie's High School is a state-funded secondary school in Marchmont, Edinburgh, Scotland. It is a comprehensive high school, educating pupils between the ages of 11 and 18, situated at the centre of Edinburgh. Edinburgh Castle and Holyrood Palace are within the catchment area of James Gillespie's High School.

Marchmont is a mainly residential area of Edinburgh, Scotland. It lies roughly one mile to the south of the Old Town, separated from it by The Meadows and Bruntsfield Links. To the west it is bounded by Bruntsfield; to the south-southwest by Greenhill and then Morningside; to the south-southeast by The Grange; and to the east by Sciennes.