James Madison High School is a public high school in San Diego, California. It is part of the San Diego Unified School District. Madison's 50-acre (200,000 m2) campus opened in 1962. Serving almost 1,100 students in grades 9–12, it is located in the Clairemont Mesa East neighborhood, north of Balboa Ave, south of Clairemont Mesa Blvd, and west of Interstate 805.

Clairemont is a community within the city of San Diego, California, United States. It has a population of about 81,600 residents and an area of roughly 13.3 square miles (34 km2). Clairemont Mesa is bordered by Interstate 805 on the east, Interstate 5 to the west, State Route 52 to the north, and the community of Linda Vista to the south. The community of Clairemont Mesa can be subdivided into the neighborhoods of North Clairemont, Clairemont Mesa East, Clairemont Mesa West, Bay Park, and Bay Ho.