The James Whitcomb Riley was a passenger train that operated between Chicago, Illinois, and Cincinnati, Ohio, via Indianapolis, Indiana. Originally operated by the New York Central Railroad, it was taken over by Amtrak in 1971. Under Amtrak, it merged with the Chesapeake & Ohio Railway's George Washington to become a Chicago-Washington/Newport News train. In 1977, it was renamed the Cardinal, which remains in operation.

The Hilltopper was a passenger train operated by Amtrak in the Mid-Atlantic region of the United States. It ran daily from South Station in Boston, Massachusetts to Catlettsburg station in Catlettsburg, Kentucky. The 1,674 mi (2,694 km) run made 34 stops in 11 states and the District of Columbia.