Jamestown is a town in the Mid North region of South Australia 207 kilometres (129 mi) north of Adelaide. It lies on the banks of the Belalie Creek and on the Crystal Brook-Broken Hill railway line between Gladstone and Peterborough, and ultimately on the main line linking Adelaide and Perth to Sydney. Jamestown is the council seat of its local municipality, Northern Areas Council. Jamestown is in the South Australian Legislative Assembly electoral district of Stuart and the federal Division of Grey.

Sir John Alexander Cockburn was Premier of South Australia from 27 June 1889 to 18 August 1890.