Jane Frances Kaczmarek is an American actress. She is best known for her role as Lois on the Fox television sitcom Malcolm in the Middle (2000–2006), which earned her three Golden Globe nominations and seven Primetime Emmy nominations. She also appeared as Linda in Equal Justice (1990–1991), Judge Trudy Kessler in Raising the Bar (2008–2009), Ann in Falling in Love (1984), Emily in The Heavenly Kid (1985), and Gayle in 6 Balloons (2018). She had recurring roles as Holly in Cybill and as Maureen Cutler in Frasier and is also known for a large number of recurring and guest-starring roles in various television shows. Kaczmarek was a replacement for the character of Bella in the Broadway production of Neil Simon's Lost In Yonkers.

Malcolm in the Middle is an American sitcom created by Linwood Boomer for Fox. The series premiered on January 9, 2000, and ended on May 14, 2006, after seven seasons consisting of 151 episodes.