National Route 1 is a major highway on the island of Honshū in Japan. It connects Chūō, Tokyo in the Kantō region with the city of Osaka, Osaka Prefecture in the Kansai region, passing through the Chūbu region en route. It follows the old Tōkaidō westward from Tokyo to Kyoto, and the old Kyo Kaidō from there to Osaka. Between Tokyo and Aichi Prefecture it parallels the Tomei Expressway; from there to Mie Prefecture, the Higashi-Meihan Expressway, and from Shiga Prefecture to Osaka, the Meishin Expressway. It has a total length of 760.9 kilometers (472.8 mi). At its eastern terminus in Nihonbashi, Chūō, Tokyo, it meets National Routes 4, 6, 14, 15, 17, and 20. At its western terminus in Umeda, Kita-ku, Osaka, it links with Routes 2, 25, 26 and other highways.

National Route 6 is a Japanese highway from Tokyo to Sendai that goes through the cities Mito, Iwaki and Sōma. It traces the old Mito Kaidō route from Tokyo to Mito, and, for much of its 353.6-kilometer (219.7 mi) route, it runs parallel to the Jōban railway line and the Jōban Expressway.