National Route 279 is a national highway of Japan that traverses the prefectures of Aomori and Hokkaido, as well as the Tsugaru Strait that separates them. The 134.0-kilometer (83.3 mi) highway begins at an intersection with National Route 5 in Hakodate, then crosses the Tsugaru Strait on a ferry from Hakodate to Ōma, Aomori, that it shares with National Route 279, where it then travels south through eastern Aomori Prefecture, passing through the city of Mutsu before ending at an intersection with National Route 4 in Noheji.

Japan has a nationwide system of national highways distinct from the expressways. The Ministry of Land, Infrastructure, Transport and Tourism and other government agencies administer the national highways. Beginning in 1952, Japan classified these as Class 1 or Class 2. Class 1 highways had one- or two-digit numbers, while Class 2 highways had three-digit numbers. For example, routes 1 and 57 were Class 1 highways while 507 was a Class 2 highway.