Thomas Jefferson University Hospitals Inc, branded as Jefferson Health, is a multi-state non-profit health system whose flagship hospital is Thomas Jefferson University Hospital in Center City Philadelphia. The health system's hospitals serve as the teaching hospitals of Thomas Jefferson University. Thomas Jefferson University and Jefferson Health are integrated together as two arms of the same organization. It has a single board of directors and produces joint financial statements. The CEO of Thomas Jefferson University and Jefferson Health is Joseph G. Cacchione, MD.

Thomas Jefferson University Hospital is the flagship hospital of Jefferson Health, a multi-state non-profit health system based in Philadelphia. The hospital serves as the teaching hospital for Thomas Jefferson University. With 937 licensed beds and 63 operating rooms, it is the second-largest hospital in Pennsylvania as of 2018.