Jeffersonville High School is a public high school located in Jeffersonville, Indiana. The school serves students in grades 9 through 12 from Jeffersonville, Utica, and sections of Clarksville not covered by that town's own high school. The school's enrollment for the 2014–2015 school year was 2,051 students, with 123 teachers. The current principal is Pam Hall. Jeffersonville is in the school district of Greater Clark County Schools. This school district includes Charlestown addresses that are connected with the city of Jeffersonville. While most schools in other counties have a majority European ratio of students, Jeffersonville total minority enrollment is 36%.

Jeffersonville is a city and the county seat of Clark County, Indiana, United States, situated along the Ohio River. Locally, the city is often referred to by the abbreviated name Jeff. It lies directly across the Ohio River to the north of Louisville, Kentucky, along I-65. The population was 49,447 at the 2020 census.