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Jerry Garcia

Jerome John "Jerry" Garcia was an American singer-songwriter and guitarist, best known for his work as the lead guitarist and as a vocalist with the band the Grateful Dead, which came to prominence during the counterculture era in the 1960s. Although he disavowed the role, Garcia was viewed by many as the leader or "spokesman" of the group; as one of its founders, Garcia performed with the Grateful Dead for their entire 30-year career. Garcia founded and participated in a variety of side projects, including the Saunders–Garcia Band, the Jerry Garcia Band, Old & In the Way, the Garcia/Grisman acoustic duo, Legion of Mary, the New Riders of the Purple Sage, he released several solo albums, contributed to a number of albums by other artists over the years as a session musician. He was well known for his distinctive guitar playing, was ranked 13th in Rolling Stone's "100 Greatest Guitarists of All Time" cover story in 2003. In the 2015 version of the list he was ranked at #46. Garcia was renowned for his musical and technical ability his ability to play a variety of instruments, his ability to sustain long improvisations with the Grateful Dead.

Garcia believed that improvisation took stress away from his playing and allowed him to make spur of the moment decisions that he would not have made intentionally. In an interview with Rolling Stone, Garcia noted that "my own preferences are for improvisation, for making it up as I go along; the idea of picking, of eliminating possibilities by deciding, that's difficult for me". Garcia's improvisation techniques were lauded for their ability to span genres, as well as his ability to employ modal guitar playing, he was a proponent of using the Mixolydian mode, a scale which utilised a flattened 7th note. In life, Garcia struggled with diabetes, in 1986 went into a diabetic coma that nearly cost him his life. Although his overall health improved somewhat after that, he continued to struggle with obesity and longstanding heroin and cocaine addictions, he was staying in a California drug rehabilitation facility when he died of a heart attack in August 1995 at the age of 53. Garcia's ancestors on his father's side were from Galicia in northwest Spain.

His mother's ancestors were Swedish. He was born in the Excelsior District of San Francisco, California, on August 1, 1942, to Jose Ramon "Joe" Garcia and Ruth Marie "Bobbie" Garcia, herself born in San Francisco, his parents named him after composer Jerome Kern. Jerome John was their second child, preceded by Clifford Ramon "Tiff", born in 1937. Shortly before Clifford's birth, their father and a partner leased a building in downtown San Francisco and turned it into a bar in response to Jose being blackballed from a musicians' union for moonlighting. Garcia was influenced by music at an early age, his father was his mother enjoyed playing the piano. His father's extended family—which had emigrated from Spain in 1919—would sing during reunions. In 1946 two-thirds of four year-old Garcia's right middle finger was cut off by his brother in a wood splitting accident while the family was vacationing in the Santa Cruz Mountains. Garcia confided that he used it to his advantage in his youth, showing it off to other children in his neighborhood.

Less than a year after this incident his father died in a fly fishing accident when the family was vacationing near Arcata in Northern California. He slipped after entering the Trinity River, part of the Six Rivers National Forest, drowned before other fishermen could reach him. Although Garcia claimed he saw the incident, Dennis McNally, author of the book A Long Strange Trip: The Inside Story of the Grateful Dead, argues Garcia formed the memory after hearing others repeat the story. Blair Jackson, who wrote Garcia: An American Life, argues a local newspaper article describing Jose's death failed to mention Jerry being present when he died. Following his father's death, Garcia's mother Ruth took over her husband's bar, buying out his partner for full ownership, she began working full-time there, sending Jerry and his brother to live nearby with her parents and William Clifford. During the five-year period in which he lived with his grandparents, Garcia enjoyed a large amount of autonomy and attended Monroe Elementary School.

At the school, Garcia was encouraged in his artistic abilities by his third grade teacher: through her, he discovered that "being a creative person was a viable possibility in life". According to Garcia, it was around this time that he was opened up to country and bluegrass music by his grandmother, whom he recalled enjoyed listening to the Grand Ole Opry, his elder brother, however, staunchly believed the contrary, insisting that Garcia was "fantasizing all... she'd been to Opry, but she didn't listen to it on the radio." It was at this point that Garcia started playing his first stringed instrument. In 1953, Garcia's mother married Wally Matusiewicz. Subsequently and his brother moved back home with their mother and new stepfather. However, due to the roughneck reputation of their neighborhood at the time, Garcia's mother moved their family to Menlo Park. During their stay in Menlo Park, Garcia became acquainted with racism and antisemitism, things he disliked intensely; the same year, Garcia was introduced to rock and roll and rhythm and blues by his brother, enjoyed listening to the likes of Ray Charles, John Lee Hooker, B. B.

King, Hank Ballard, Chuck Berry. Clifford memorized the vocals for hi

Cuando toca la campana

Cuando toca la campana is an Argentine television sitcom airing on Disney Channel in Latin American Countries. The series premiered on February 28, 2011. Created by Cristal Líquido Produçöes and starring Mariana Magaña, Leonel Deluglio, Nicole Luis, Diana Santos, Jorge Blanco, Julio Graham, Gerardo Velazquez, Stephie Camarena and Eva De Dominici, the show follows the adventures of guys who try to have fun, "When the bell rings" for the break, it is a Latin American adaptation based on the Disney Channel Italy series Quelli dell'intervallo. Cuando toca la campana revolves around the adventures of the friends and enemies Barbi, Lucia, Pablo, Rodrigo, DJ, Naty and Paola, who study in the same school and try to enjoy recess, all trying to adapt themselves and their crazy adventures. Lucia waiting for the Miguel love and him waiting for her love, Barbi doing crazy things with DJ; the show was produced by Disney Channel Latin America in association with Cristal Liquido Produçöes. Barbi, portrayed by Mariana Magaña, Barbi, is a sensitive girl.

Is distracted and shy but funny, she likes to tell illogical stories and absurd theorizing. She likes to dance a lot, a close friend of DJ, always publish the gossip he says. Miguel, portrayed by Leonel Deluglio, is a great friend. Miguel is funny and full of good vibes, he likes to solve the problems of their friends. He is in love with Lucia. Lucia, portrayed by Nicole Luis, is the popular girl in school. Is charismatic and practical, she likes to organize things, she is considered a leader but always worried about her appearance. Ana, portrayed by Diana Santos, is the smart girl at school. She's a girl, interested in ecology and she thinks save the world. Pablo, portrayed by Jorge Blanco, is the most sporting guy, it is considered the best soccer player. Rodrigo, portrayed by Julio Graham, is a distracted and confused boy, superstitious and pessimistic. "DJ", portrayed by Gerardo Velazquez, is the school gossip, he tells everything to everybody, he loves music and dancing. Natalia, portrayed by Stephi Camarena, is a girl who likes the arts, like singing, dancing and painting.

Paola, portrayed by Eva De Dominici, is a singer, but vain and only goes to school to show off, educated and will look like any other girl. A girl – Carla Medina

Creatine kinase

Creatine kinase known as creatine phosphokinase or phosphocreatine kinase, is an enzyme expressed by various tissues and cell types. CK catalyses the conversion of creatine and uses adenosine triphosphate to create phosphocreatine and adenosine diphosphate; this CK enzyme reaction is reversible and thus ATP can be generated from PCr and ADP. In tissues and cells that consume ATP especially skeletal muscle, but brain, photoreceptor cells of the retina, hair cells of the inner ear and smooth muscle, PCr serves as an energy reservoir for the rapid buffering and regeneration of ATP in situ, as well as for intracellular energy transport by the PCr shuttle or circuit, thus creatine kinase is an important enzyme in such tissues. Clinically, creatine kinase is assayed in blood tests as a marker of damage of CK-rich tissue such as in myocardial infarction, muscular dystrophy, autoimmune myositides, acute kidney injury. In the cells, the "cytosolic" CK enzymes consist of two subunits, which can be either B or M.

There are, three different isoenzymes: CK-MM, CK-BB and CK-MB. The genes for these subunits are located on different chromosomes: B on 14q32 and M on 19q13. In addition to those three cytosolic CK isoforms, there are two mitochondrial creatine kinase isoenzymes, the ubiquitous and sarcomeric form; the functional entity of the latter two mitochondrial CK isoforms is an octamer consisting of four dimers each. While mitochondrial creatine kinase is directly involved in formation of phospho-creatine from mitochondrial ATP, cytosolic CK regenerates ATP from ADP, using PCr; this happens at intracellular sites where ATP is used in the cell, with CK acting as an in situ ATP regenerator. Isoenzyme patterns differ in tissues. Skeletal muscle expresses CK-MM and low levels of CK-MB; the myocardium, in contrast, expresses CK-MM at 70% and CK-MB at 25–30%. CK-BB is predominantly expressed in brain and smooth muscle, including uterine tissue. A number of CK structures have been solved by high-resolution electron microscopy and protein X-ray crystallography.

The first X-ray structure of a creatine kinase family member solved was that of sarcomeric muscle-type mitochondrial CK followed by the structure of ubiquitous u-mtCK in 2000. ). Both mitochondrial CK isoforms are building symmetrical octameric structures with 4-fold symmetry; the atomic structure of cytosolic brain-type BB-CK was solved at 1.4! Angstroms in 1999. Cytosolic BB-CK, as well as muscle-type MM-CK are both forming banana-shaped symmetric dimers, with one active site in each subunit; the mitochondrial creatine kinase is present in the mitochondrial intermembrane space, where it regenerates phosphocreatine from mitochondrially generated ATP and creatine imported from the cytosol. Apart from the two mitochondrial CK isoenzyme forms, that is, ubiquitous mtCK and sarcomeric mtCK, there are three cytosolic CK isoforms present in the cytosol, depending on the tissue. Whereas MM-CK is expressed in sarcomeric muscle, that is, skeletal and cardiac muscle, MB-CK is expressed in cardiac muscle, BB-CK is expressed in smooth muscle and in most non-muscle tissues.

Mitochondrial mtCK and cytosolic CK are connected in circuit. PCr generated by mtCK in mitochondria is shuttled to cytosolic CK, coupled to ATP-dependent processes, e.g. ATPases, such as acto-myosin ATPase and calcium ATPase involved in muscle contraction, sodium/potassium ATPase involved in sodium retention in the kidney; the bound cytosolic CK accepts the PCr shuttled through the cell and uses ADP to regenerate ATP, which can be used as energy source by the ATPases. PCr is not only an energy buffer but a cellular transport form of energy between subcellular sites of energy production and those of energy utilization. Thus, CK enhances skeletal and smooth muscle contractility, is involved in the generation of blood pressure. CK is determined in a medical laboratory, it used to be determined in patients with chest pain but this test has been replaced by troponin. Normal values at rest are between 60 and 400 IU/L, where one unit is enzyme activity, more the amount of enzyme that will catalyze 1 μmol of substrate per minute under specified conditions This test is not specific for the type of CK, elevated.

Creatine kinase in the blood may be high in disease. Exercise increases the outflow of creatine kinase to the blood stream for up to a week, this is the most common cause of high CK in blood. Furthermore, high CK in the blood may be related to high intracellular CK such as in persons of African descent. High CK in the blood may be an indication of damage to CK-rich tissue, such as in rhabdomyolysis, myocardial infarction and myocarditis; this means creatine kinase in blood may be elevated in a wide range of clinical conditions including the use of medication such as statins. Furthermore, the isoenzyme determination has been used extensively as an indication for myocardial damage in heart attacks. Troponin measurement has replaced this in many hospitals, although some centers still rely on CK-MB. Reference ranges for blood tests Simply st